NAD+

Nicotinamide Adenine Dinucleotide (NAD+) is a dinucleotide composed of adenine and nicotinamide nucleotides joined by a phosphoanhydride bridge. With a molecular weight of 663.43 g/mol, it exists in two interconvertible redox states: NAD+ (oxidized) and NADH (reduced). In research settings, NAD+ is valued for its role as both a coenzyme and a signaling molecule — driving redox chemistry while simultaneously acting as a substrate for regulatory enzymes including sirtuins, PARPs, and CD38.

Research applications are broad across bioenergetics, mitochondrial biology, and metabolic science. Among the most studied research territories is its role as the obligatory substrate for sirtuin deacylase enzymes (SIRT1–7). PARP enzyme research represents a further application domain — PARP-1 and related family members are major consumers of cellular NAD+ recruited to sites of DNA damage. Researchers studying mitochondrial respiratory chain function use exogenous NAD+ as a substrate to probe electron transport efficiency.

Every batch of NAD+ is independently analyzed by third-party laboratories using HPLC prior to release. We guarantee a minimum purity of ≥99% on all NAD+ preparations. Third-party verification eliminates the confirmation bias inherent in in-house quality assurance and provides a defensible, documented purity claim.

This product is strictly for research and laboratory use only. It is not approved by the FDA or any global regulatory body for human consumption, veterinary use, or therapeutic application. The purchaser assumes all responsibility for the proper handling, storage, and application of this compound. It must only be handled by qualified professionals in a controlled laboratory setting. By purchasing this product, you agree to abide by all local and international laws regarding the use of research chemicals.