LL-37

LL-37 is a 37-amino-acid alpha-helical peptide with a molecular weight of approximately 4493.3 g/mol. It is expressed by neutrophils, macrophages, and epithelial cells and represents the active antimicrobial domain of human cathelicidin. Its amphipathic structure enables membrane disruption of microbial targets while also mediating immunomodulatory functions through host cell receptor interactions.

Research applications include antimicrobial activity assays, innate immunity studies, wound healing biology, biofilm disruption research, and immunomodulatory signaling investigations. LL-37 is used in comparative studies against other antimicrobial peptides and as a reference standard in host defense peptide pharmacology.

Every batch of LL-37 is synthesized using Solid-Phase Peptide Synthesis (SPPS) and purified via preparative HPLC to eliminate truncated sequences and synthesis byproducts. Final identity confirmation is performed via Electrospray Ionization Mass Spectrometry (ESI-MS), verifying exact molecular weight. Each lot ships with a Certificate of Analysis documenting purity exceeding 99%, giving researchers traceable, batch-specific verification before use in any laboratory protocol.

This product is strictly for research and laboratory use only. It is not approved by the FDA or any global regulatory body for human consumption, veterinary use, or therapeutic application. The purchaser assumes all responsibility for the proper handling, storage, and application of this compound. It must only be handled by qualified professionals in a controlled laboratory setting. By purchasing this product, you agree to abide by all local and international laws regarding the use of research chemicals.